N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE Chemical Properties

Boiling point:

78-80 °C (7 mmHg)

refractive index 

1.45-1.452

storage temp. 

0-6°C

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36/37

MSDS

• Language:English Provider:ACROS

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE Usage And Synthesis

Chemical Properties

CLEAR PALE YELLOW LIQUID

Uses

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE conveniently effects the transformation of ketones and aldehydes to homologated nitriles, amines, aldehydes, and ketones.

Synthesis

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE is easily synthesized by a two-step procedure (eq 1).1 Initially, the condensation of t-Butylamine with either N,N-Dimethylformamide or dimethylformamide dimethyl acetal cleanly affords N′-t-Butyl-N,N-dimethylformamidine. Subsequent lithiation and silylation with Chlorotrimethylsilane results in a 70% overall yield of the purified title reagent.

storage

The reagent should be handled in a fume hood. Refrigeration should be used for prolonged storage.

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE(80376-66-5)Related Product Information

• (Trimethylsilyl)methylamine
• N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE
• N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE