EXENDIN (5-39)
EXENDIN (5-39) Basic information
- Product Name:
- EXENDIN (5-39)
- Synonyms:
-
- EXENDIN (5-39)
- THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
- Exendin 4 (5-39)amide
- Exendin4(5-39)
- CAS:
- 196109-27-0
- MW:
- 0
- Mol File:
- Mol File
EXENDIN (5-39) Chemical Properties
- form
- Solid
- color
- White to off-white
- Sequence
- Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
EXENDIN (5-39) Usage And Synthesis
Uses
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].
in vivo
Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1].
| Animal Model: | Wistar rats (3 weeks old and 18 days pregnant)[1] |
| Dosage: | 0.3 μg |
| Administration: | Intracerebroventricular injection; 0.3 μg; once daily; 1-week |
| Result: | Inhibited GLT-1 protein levels and inhibited long-term depression in rats. |
References
[1] Kazuma Kobayashi, et al. Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. 2013 Apr 10;1505:1-10. DOI:10.1016/j.brainres.2013.01.012
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