ASP-ARG-VAL-TYR-ILE-HIS-PRO Chemical Properties

Melting point:

>202°C (dec.)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)

form 

powder

pka

3.29±0.20(Predicted)

color 

White to Off-White

Water Solubility 

Soluble to 1 mg/ml in water

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ASP-ARG-VAL-TYR-ILE-HIS-PRO Usage And Synthesis

Uses

Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.

Definition

ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.

Biological Activity

ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.

Biochem/physiol Actions

Angiotensin I metabolite that is an AT2 receptor agonist.

storage

Store at -20°C

References

1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)

ASP-ARG-VAL-TYR-ILE-HIS-PRO(51833-78-4)Related Product Information

• ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT
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• EC 3.4.15.1
• NA
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• H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH,ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER
• ASP-ARG-VAL-TYR-ILE-HIS-PRO
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• ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER,H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH
• ASP-ARG-VAL-TYR-ILE-HIS-PRO-LEU-HIS-LEU-LEU-TYR-TYR-SER
• ASP-ARG-VAL-TYR-ILE-HIS-PRO-ALA
• ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS,H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-OH
• ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH,ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
• BIOTINYL-ASP-ARG-VAL-TYR-ILE-HIS-PRO-OH
• H-GLY-GLY-HIS-GLY-OH