2-Methylindole-3-carboxaldehyde Chemical Properties

Melting point:

200-201 °C (lit.)

Boiling point:

344.3±22.0 °C(Predicted)

Density 

1.226±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

16.08±0.30(Predicted)

form 

Powder

color 

Brown

CAS DataBase Reference

5416-80-8(CAS DataBase Reference)

EPA Substance Registry System

1H-Indole-3-carboxaldehyde, 2-methyl- (5416-80-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

37/39-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-Methylindole-3-carboxaldehyde Usage And Synthesis

Chemical Properties

Brown powder

Uses

Reactant for preparation of:• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• ;Fluorescent sensors (BODIPY)2• ;Antimicrobial agents against methicillin-resistant Staphylococcus aureus3• ;G protein-coupled receptor CRTh2 antagonists4• ;Inhibitors of PI3 kinase-α5• ;Antitubercular agents6• ;Anti-inflammatory agents7• ;Mycobacterium tuberculosis protein tyrosine phosphatase B8• ;Glucocorticoid receptor ligands9• ;Agents stimulating neurite outgrowth10

Uses

Reactant for preparation of:

• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Fluorescent sensors (BODIPY)
• Antimicrobial agents against methicillin-resistant Staphylococcus aureus
• G protein-coupled receptor CRTh2 antagonists
• Inhibitors of PI3 kinase-α
• Antitubercular agents
• Anti-inflammatory agents
• Mycobacterium tuberculosis protein tyrosine phosphatase B
• Glucocorticoid receptor ligands
• Agents stimulating neurite outgrowth

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 31, p. 2892, 1983 DOI: 10.1248/cpb.31.2892

General Description

Oxidative activation of 2-methylindole-3-carboxaldehyde via N-heterocyclic carbene organocatalysis generates heterocyclic ortho-quinodimethane as a key intermediate.

2-Methylindole-3-carboxaldehyde(5416-80-8)Related Product Information

• Paraformaldehyde
• Methylparaben
• Kresoxim-methyl
• Indole
• 2-Methylindole
• Methyl acrylate
• Thiophanate-methyl
• Bensulfuron methyl
• Indole-3-carboxaldehyde
• Methyl
• 1,2,3,9-TETRAHYDRO-4H-9-METHYL-CARBAZOLE-4-ONE
• (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER
• 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one
• 1-Methyl-2-phenylindole-3-carboxaldehyde
• Ethyl 5-acetyloxy-1,2-dimethylindole-3-carboxylate
• Methyl bromide
• 1-METHYLINDOLE-3-CARBOXALDEHYDE,1-Methylindole-3-carboxaldehyde, 98+%,1-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC)
• 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE