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1-Methylindole-3-carboxaldehyde

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1-Methylindole-3-carboxaldehyde Basic information

Product Name:
1-Methylindole-3-carboxaldehyde
Synonyms:
  • TIMTEC-BB SBB010057
  • RARECHEM AH BS 0121
  • 1 METHYLINDOLE-3-ALDEHYDE
  • 1-METHYLINDOLE-3-CARBALDEHYDE
  • 1-METHYLINDOLE-3-CARBOXALDEHYDE
  • 1-METHYL-1H-INDOLE-3-CARBALDEHYDE
  • 1-METHYL-1H-INDOLE-3-CARBOXALDEHYDE
  • AKOS JY2082515
CAS:
19012-03-4
MF:
C10H9NO
MW:
159.18
EINECS:
242-750-3
Product Categories:
  • Heterocycle-Indole series
  • Heterocycles
  • Indoles and derivatives
  • Building Blocks
  • Heterocyclic Building Blocks
  • Indoles
  • ALDEHYDE
  • Indole
  • Heterocyclic Compounds
Mol File:
19012-03-4.mol
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1-Methylindole-3-carboxaldehyde Chemical Properties

Melting point:
70-72 °C (lit.)
Boiling point:
186-189 °C(Press: 3-4 Torr)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Crystalline Powder and Chunks
color 
Light yellow to orange or brown
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
BRN 
121302
CAS DataBase Reference
19012-03-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900

MSDS

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1-Methylindole-3-carboxaldehyde Usage And Synthesis

Chemical Properties

light yellow to orange or brown crystalline powder

Uses

Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.

Uses

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

Synthesis Reference(s)

Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960

General Description

1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.

1-Methylindole-3-carboxaldehyde Preparation Products And Raw materials

Preparation Products

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