1-Methylindole-3-carboxaldehyde Chemical Properties

Melting point:

70-72 °C (lit.)

Boiling point:

186-189 °C(Press: 3-4 Torr)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Crystalline Powder and Chunks

color 

Light yellow to orange or brown

Water Solubility 

Insoluble in water.

Sensitive 

Air Sensitive

BRN 

121302

CAS DataBase Reference

19012-03-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:1-Methyl-1H-indole-3-carbaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Methylindole-3-carboxaldehyde Usage And Synthesis

Chemical Properties

light yellow to orange or brown crystalline powder

Uses

Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.

Uses

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

Synthesis Reference(s)

Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960

General Description

1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.

1-Methylindole-3-carboxaldehyde(19012-03-4)Related Product Information

• Bensulfuron methyl
• Methylparaben
• Indole
• Thiophanate-methyl
• Kresoxim-methyl
• Methyl acrylate
• 2-Methylindole
• Indole-3-carboxaldehyde
• 1-Methylindole
• Methyl
• Methyl bromide
• Parathion-methyl
• 1-Methyl-2-phenylindole-3-carboxaldehyde
• 1-BENZYL-1H-INDOLE-3-CARBALDEHYDE
• 1,3-DIACETYLINDOLE
• Ethyl 5-acetyloxy-1,2-dimethylindole-3-carboxylate
• Ondansetron hydrochloride
• 1-BENZYLINDOLE-3-CARBOXYLIC ACID