-N7-DGTP Chemical Properties

Density 

2.48±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

solution

pka

0.97±0.50(Predicted)

color 

colorless

biological source

Porcine muscle
rabbit muscle

InChIKey

CEGUJIMDPFZZHS-JEBNKXSCNA-M

SMILES

C12NC(=NC(=O)C=1C=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP([O-])(=O)O)O1)N.[Li+] |&1:10,12,14,r|

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

-N7-DGTP Usage And Synthesis

Uses

7-Deaza-dGTP is a substrate for most DNA polymerases, including Taq DNA polymerase.
7-Deaza-dGTP is used in the dideoxy-chain termination sequencing methods, in place of dGTP to overcome compression problems in gel electrophoresis when sequencing GC-rich stretches of DNA.
Partial substitution of 7-Deaza-dGTP for dGTP in PCRs can improve the product yield when the template is GC-rich (i.e., has extensive secondary structures).

General Description

7-Deaza-2′-deoxyguanosine 5′-triphosphate enhances polymerase chain reaction (PCR) product yield.

Biochem/physiol Actions

This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA ploymerases.

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