Basic information Safety Supplier Related

Tetrahydrobiopterin

Basic information Safety Supplier Related

Tetrahydrobiopterin Basic information

Product Name:
Tetrahydrobiopterin
Synonyms:
  • 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinon
  • 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinone
  • bh4
  • TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE
  • THB, 2HCL
  • 6R-BH4
  • (6R)-BH4 2HCL
  • [6R-[6R*(1R*,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE
CAS:
17528-72-2
MF:
C9H15N5O3
MW:
241.25
Mol File:
17528-72-2.mol
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Tetrahydrobiopterin Chemical Properties

Melting point:
>202°C (dec.)
Boiling point:
506.6±60.0 °C(Predicted)
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
form 
Solid
pka
14.22±0.20(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
Toxicity
mouse,LD50,intraperitoneal,258mg/kg (258mg/kg),Toxicology. Vol. 42, Pg. 183, 1986.
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Tetrahydrobiopterin Usage And Synthesis

Uses

Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.

Definition

ChEBI: 5,6,7,8-tetrahydrobiopterin is a tetrahydropterin, a member of biopterins and a diol. It has a role as a prosthetic group, a coenzyme, a nutraceutical and a human metabolite.

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