Ambazone hydrate
Ambazone hydrate Basic information
- Product Name:
- Ambazone hydrate
- Synonyms:
-
- Ambazone hydrate
- 1,4-Benzoquinone guanylhydrazone thiosemicarbazone hydrate
- Ambazone-1-hydrate
- Iversal
- Unii-byk4592A3q
- Ambazone Monohydrate
- CAS:
- 6011-12-7
- MF:
- C8H13N7OS
- MW:
- 255.30012
- Mol File:
- 6011-12-7.mol
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Ambazone hydrate Chemical Properties
- Melting point:
- 188 °C (decomp)(Solv: water (7732-18-5); ammonia (7664-41-7))
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Ambazone hydrate Usage And Synthesis
Originator
Ambazone,Generic
Manufacturing Process
To a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water. The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L of water at 100°C. The solution is filtered and added to an aqueous ammonium solution. Blue residue of p-benzoquinone amidinohydrazone thiosemicarbazone is filtered and dried, melting point 188°C (decomp.).
Therapeutic Function
Antiseptic