Ethyl 4-fluoro-3-nitrobenzoate Chemical Properties

Melting point:

45.3 °C

Boiling point:

312.3±22.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

crystalline powder

color 

Pale creamy lemon

CAS DataBase Reference

367-80-6(CAS DataBase Reference)

Safety Information

HS Code 

2918300090

Ethyl 4-fluoro-3-nitrobenzoate Usage And Synthesis

Synthesis

Step 1: 5.00 g (27.0 mmol) of 4-fluoro-3-nitrobenzoic acid was dissolved in 50 mL of saturated ethanolic hydrochloric acid solution (1.25 M) and the reaction was refluxed for 15 hours. After completion of the reaction, the reaction mixture was evaporated using a rotary evaporator. Purification by fast column chromatography [silica gel, eluent petroleum ether/ethyl acetate (4:1)] afforded 5.48 g (25.7 mmol, 95%) of ethyl 4-fluoro-3-nitrobenzoate as a colorless solid. Thin layer chromatography (TLC) Rf = 0.48 [silica gel, petroleum ether/ethyl acetate (4:1)]. Mass Spectrometry (ESI) m/z: [M + H]+ calculated value of 214.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1859 - 1863
[2] Patent: US2007/112033, 2007, A1. Location in patent: Page/Page column 17-18
[3] Patent: US2013/79306, 2013, A1. Location in patent: Paragraph 0226; 0227; 0228; 0229
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 16, p. 7262 - 7272
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1646 - 1663

Ethyl 4-fluoro-3-nitrobenzoate(367-80-6)Related Product Information

• Ethanol
• Ethyl acrylate
• Ethyl 2-chloromethylbenzoate
• Ethylbenzene
• Ethylparaben
• CHLOROETHANE
• 4-Fluoronitrobenzene
• Urethane
• Ethyl cellulose
• Ethyl benzoate
• 1-Fluoro-2-nitrobenzene
• Ethyl formate
• Ethyl acetate
• Fluorine
• 2-AMINO-6-FLUORO-3-NITROBENZOIC ACID ETHYL ESTER
• 4-Fluoro-3-nitrobenzoic acid
• Diethyl ether
• Ethyl chloroformate