Sodium D-pantothenate
Sodium D-pantothenate Basic information
- Product Name:
- Sodium D-pantothenate
- Synonyms:
-
- (r)-n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine monosodium salt
- SODIUM D-PANTOTHENATE
- SODIUM PANTHOTENATE
- SODIUM PANTOTHENATE
- beta-alanine,n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(t
- heta)-
- monosodiumsalt,d-pantothenicaci
- N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(R)-.beta.-Alanine
- CAS:
- 867-81-2
- MF:
- C9H16NNaO5
- MW:
- 241.22
- EINECS:
- 212-768-6
- Product Categories:
-
- API
- Biochemistry
- Vitamins
- Vitamins and derivatives
- OLED
- Mol File:
- 867-81-2.mol
Sodium D-pantothenate Chemical Properties
- Melting point:
- 171-178 °C(lit.)
- alpha
- D25 +27.1° (c = 2)
- refractive index
- 27 ° (C=5, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- LogP
- -0.849 (est)
- CAS DataBase Reference
- 867-81-2(CAS DataBase Reference)
- EPA Substance Registry System
- .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, monosodium salt (867-81-2)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-48-41-37/38-20/21/22
- Safety Statements
- 26-36-45-36/37/39-22-24/25
- HS Code
- 29241990
- Hazardous Substances Data
- 867-81-2(Hazardous Substances Data)
MSDS
- Language:English Provider:(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine monosodium salt
Sodium D-pantothenate Usage And Synthesis
Description
Sodium D-pantothenate is the sodium salt of the biological active enantiomer of pantothenic acid (vitamin B5). As D-pantothenic acid is a precursor in the biosynthesis of coenzyme A, sodium D- pantothenate is used in the synthesis of coenzyme A. It is also used in foods as a dietary supplement.
References
[1] George A. Burdock, Encyclopedia of Food and Color Additives, volume 3, 1996
Chemical Properties
White crystal or powder
Uses
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].
in vivo
Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2].
| Animal Model: | Female ICR mice weighing 29-35 g[2] |
| Dosage: | 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered) |
| Administration: | Injected intraperitoneally (i.p.) on day 8.5 of gestation |
| Result: | Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced. |
IC 50
Human Endogenous Metabolite
Purification Methods
Crystallise the salt from absolute EtOH. It is very hygroscopic (keep in sealed ampoules). The free acid is a viscous hygroscopic oil with [] 25D +37.5o (c 5, H2O), easily destroyed by acids and bases. [Beilstein 4 IV 2569.]
References
[1] Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. DOI:10.1007/s11356-017-0774-8
[2] M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. DOI:10.1002/tera.1420520306
Sodium D-pantothenate Supplier
- Tel
- 0578-2989276 18917093248
- 982669049@qq.com
- Tel
- 16650708709
- hnyingchuang@163.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-61259108 18621169109
- market03@meryer.com
- Tel
- +86 351 7031519
- sales@RHFChem.com
Sodium D-pantothenate (867-81-2)Related Product Information
- Sodium bicarbonate
- Calcium D-Pantothenate
- Butylated Hydroxytoluene
- Trisodium citrate dihydrate
- Dimethyl sebacate
- ETHANE
- Dimethyl fumarate
- Dimethyl sulfoxide
- D-PANTOTHENIC ACID
- Sodium chlorite
- Dimethyl ether
- EC 2.6.1.2
- Sodium gluconate
- Sodium carbonate
- β-Alanine
- Butylated hydroxyanisole
- Dimethyl phthalate
- Sodium formate