Heterophyllin B
Heterophyllin B Basic information
- Product Name:
- Heterophyllin B
- Synonyms:
-
- Heterophyllin B
- Heterophylin B
- Prince Ginseng Cyclic Peptide B
- Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl)
- Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl)
- (6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone
- (6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone
- CAS:
- 145459-19-4
- MF:
- C40H58N8O8
- MW:
- 778.94
- EINECS:
- 300-006-6
- Product Categories:
-
- reagent
- standard substance
- Mol File:
- 145459-19-4.mol
Heterophyllin B Chemical Properties
- Boiling point:
- 1159.7±65.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- pka
- 13.44±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Heterophyllin B Usage And Synthesis
Chemical Properties
White crystal, easily soluble in methanol, derived from Radix Radix.
Uses
Taizishencyclopeptide B has the functions of invigorating qi and blood, invigorating body fluid and invigorating the spleen and stomach. And it was used for content determination/identification/pharmacological experiments, etc.
Biological Activity
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. It can be used in esophageal cancer research.
in vitro
Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0 -50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells.
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Cell Viability Assay
| Cell Line: | ECA-109 cells |
| Concentration: | 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM |
| Incubation Time: | 12, 24 and 48 hours |
| Result: | Decrease cell viability at high concentrations. |
Western Blot Analysis
| Cell Line: | ECA-109 cells |
| Concentration: | 0 μM, 10 μM, 25 μM, 50 μM |
| Incubation Time: | 6 hours |
| Result: | Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. |
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