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N-DesMethyl Netupitant

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N-DesMethyl Netupitant Basic information

Product Name:
N-DesMethyl Netupitant
Synonyms:
  • N-DesMethyl Netupitant
  • Netupitant metabolite N-desmethyl Netupitant
  • 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide
  • Netupitant Impurity B
  • Netupitant N-Desmethyl Impurity
  • Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
  • Netupitant Impurity TMNT
  • Netupitant Impurities B
CAS:
290296-72-9
MF:
C29H30F6N4O
MW:
564.57
Mol File:
290296-72-9.mol
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N-DesMethyl Netupitant Chemical Properties

Boiling point:
607.5±55.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.51±0.10(Predicted)
InChIKey
SRVSDBHUBFLSFE-UHFFFAOYSA-N
SMILES
C(N(C)C1=C(C2=CC=CC=C2C)C=C(N2CCNCC2)N=C1)(=O)C(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(C)C
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N-DesMethyl Netupitant Usage And Synthesis

Uses

N-Desmethyl Netupitant is a derivative of Netupitant (N390950) which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. Netupitant (N390950) is achiral and orally active.

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