CPNQ
CPNQ Basic information
- Product Name:
- CPNQ
- Synonyms:
-
- 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
- B2
- Linazolamide intermediate B impurity 2
- (4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
- SIRT2 Inhibitor, B2
- Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-
- Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
- SIRT2-IN-8
- CAS:
- 115687-05-3
- MF:
- C20H17ClN4O3
- MW:
- 396.83
- Mol File:
- 115687-05-3.mol
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CPNQ Chemical Properties
- Melting point:
- 174-176°C
- Boiling point:
- 645.5±55.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- H2O: insoluble <2mg/mL
- pka
- 2.30±0.29(Predicted)
- form
- solid
- color
- brown
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
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CPNQ Usage And Synthesis
Uses
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.
Definition
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.
Biological Activity
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.
CPNQSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Zhengzhou Guancheng Laboratory equipment Sales
- Tel
- 0371-88888888 272369594
- 2723695949@qq.com
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
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