ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > EX-527 (R-enantioMer)
EX-527 (R-enantioMer)
EX-527 (R-enantioMer) Basic information
- Product Name:
- EX-527 (R-enantioMer)
- Synonyms:
-
- EX-527 (R-enantioMer)
- (R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
- EX-527(R‰
- (R)-Selisistat
- (R)-SELISISTAT; EX-527(R); EX 527(R); EX527(R);
- Sirtuin,Selisistat R enantiomer,inhibit,Selisistat Renantiomer,Inhibitor,(R)-Selisistat
- 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1R)-
- Selisistat R-enantiomer, 10 mM in DMSO
- CAS:
- 848193-69-1
- MF:
- C13H13ClN2O
- MW:
- 248.71
- Mol File:
- 848193-69-1.mol
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EX-527 (R-enantioMer) Chemical Properties
- Boiling point:
- 531.7±38.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 16.12±0.40(Predicted)
- color
- Light yellow to yellow
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EX-527 (R-enantioMer) Usage And Synthesis
Uses
(R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
Definition
ChEBI: (R)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has R configuration. It is the inactive enantiomer. It is an enantiomer of a (S)-selisistat.
References
[1] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v
EX-527 (R-enantioMer)Supplier
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