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N-Benzyloxycarbonyl-D-proline

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N-Benzyloxycarbonyl-D-proline Basic information

Product Name:
N-Benzyloxycarbonyl-D-proline
Synonyms:
  • Cbz-D-Pro
  • PROLINA-Z-D
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL)ESTER, (2R)-
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (R)-
  • 1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID
  • (R)-Z-pyrrolidine-2-carboxylic acid
  • Z-D-proline≥ 98% (HPLC)
  • BENZYLOXYCARBONYL-D-PROLINE
CAS:
6404-31-5
MF:
C13H15NO4
MW:
249.26
EINECS:
229-021-5
Product Categories:
  • Amino Acids
  • Amino Acids (N-Protected)
  • Proline [Pro, P]
  • Biochemistry
  • Cbz-Amino Acids
  • Cbz-Amino acid series
  • Z-Amino Acids and Derivatives
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Proline
Mol File:
6404-31-5.mol
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N-Benzyloxycarbonyl-D-proline Chemical Properties

Melting point:
76-78 °C(lit.)
alpha 
40 º (c=2, EtOH)
Boiling point:
432.3±45.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
refractive index 
40 ° (C=2, EtOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
3.99±0.20(Predicted)
form 
Crystalline Powder or Powder
color 
White
optical activity
[α]25/D +40.2°, c = 2 in ethanol
BRN 
485188
InChIKey
JXGVXCZADZNAMJ-LLVKDONJSA-N
CAS DataBase Reference
6404-31-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29339900

MSDS

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N-Benzyloxycarbonyl-D-proline Usage And Synthesis

Chemical Properties

White crystalline powder or powder

Uses

N-(Benzyloxycarbonyl)-D-proline is an an N-Cbz-protected form of D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.

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