"Desloratadine Citrate Disodium"
"Desloratadine Citrate Disodium" Basic information
- Product Name:
- "Desloratadine Citrate Disodium"
- Synonyms:
-
- MW:
- 0
- Mol File:
- Mol File
"Desloratadine Citrate Disodium" Chemical Properties
- Melting point:
- 150-151°C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- White to Beige
"Desloratadine Citrate Disodium" Usage And Synthesis
Uses
Desloratadine (Loratadine EP Impurity D; Loratadine USP Related Compound A) is an active metabolite of Loratadine (L469575) and used as an oral non-sedating antihistamine to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria (1,2,3).
Clinical Use
Antihistamine:
Symptomatic relief of allergy such as hay fever,
urticaria
Drug interactions
Potentially hazardous interactions with other drugs
Antivirals: concentration possibly increased by
ritonavir.
Metabolism
Desloratadine is the primary active metabolite of loratadine. Approximately 40% of the dose is excreted in the urine and 42% in the faeces over a 10 day period and mainly in the form of conjugated metabolites. Approximately 27% of the dose is eliminated in the urine during the first 24 hours. Less than 1% of the active substance is excreted unchanged in the active form, as desloratadine.