Basic information Safety Supplier Related

MMAF-OMe

Basic information Safety Supplier Related

MMAF-OMe Basic information

Product Name:
MMAF-OMe
Synonyms:
  • MMAF-OMe
  • MONOMETHYL AURISTATIN F METHYL ESTER
  • L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
  • ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin
  • Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate
  • MMAF-OMe, 10 mM in DMSO
CAS:
863971-12-4
MF:
C40H67N5O8
MW:
746
Mol File:
863971-12-4.mol
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MMAF-OMe Chemical Properties

Boiling point:
871.8±65.0 °C(Predicted)
Density 
1.095±0.06 g/cm3(Predicted)
pka
13.89±0.46(Predicted)
form 
Solid
color 
Off-white to light yellow
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MMAF-OMe Usage And Synthesis

Uses

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

IC 50

Auristatin

References

[1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881

MMAF-OMeSupplier

MedChemexpress LLC
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Tianjin Chempharmatech Co.,Ltd.
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022-66211079 13212288319
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Shanghai Send Pharmaceutical Technology Co., Ltd.
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021-58088081 Q2635253576
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Shanghai YuanYe Biotechnology Co., Ltd.
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Musechem
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+1-800-259-7612
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