MMAF-OMe
MMAF-OMe Basic information
- Product Name:
- MMAF-OMe
- Synonyms:
-
- MMAF-OMe
- MONOMETHYL AURISTATIN F METHYL ESTER
- L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
- ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin
- Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate
- MMAF-OMe, 10 mM in DMSO
- CAS:
- 863971-12-4
- MF:
- C40H67N5O8
- MW:
- 746
- Mol File:
- 863971-12-4.mol
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MMAF-OMe Chemical Properties
- Boiling point:
- 871.8±65.0 °C(Predicted)
- Density
- 1.095±0.06 g/cm3(Predicted)
- pka
- 13.89±0.46(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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MMAF-OMe Usage And Synthesis
Uses
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
IC 50
Auristatin
References
[1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881
MMAF-OMeSupplier
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Tianjin Chempharmatech Co.,Ltd.
- Tel
- 022-66211079 13212288319
- sales@chempharmatech.com
Shanghai Send Pharmaceutical Technology Co., Ltd.
- Tel
- 021-58088081 Q2635253576
- hailey@shsendpharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Musechem
- Tel
- +1-800-259-7612
- info@musechem.com