FHPI HCL
FHPI HCL Basic information
- Product Name:
- FHPI HCL
- Synonyms:
-
- SB202190 HCL
- SB 202190, HYDROCHLORIDE
- FHPI HCL
- 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-iMidazol-2-yl]phenol Monohydrochloride
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate
- 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
- SB 202190 monohydrochloride hydrate
- 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE HCL
- CAS:
- 350228-36-3
- MF:
- C20H15ClFN3O
- MW:
- 367.8
- Mol File:
- Mol File
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FHPI HCL Chemical Properties
- storage temp.
- -20°C
- solubility
- DMSO: ≥12mg/mL
- form
- solid
- color
- white to beige
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FHPI HCL Usage And Synthesis
Uses
The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.
General Description
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
Biochem/physiol Actions
SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.
FHPI HCLSupplier
J & K SCIENTIFIC LTD.
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NCE Biomedical Co.,Ltd.
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SYN|thesis med chem P/L
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Sigma-Aldrich
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- 021-61415566 800-8193336
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