CYCLIC-PIFITHRIN-ALPHA
CYCLIC-PIFITHRIN-ALPHA Basic information
- Product Name:
- CYCLIC-PIFITHRIN-ALPHA
- Synonyms:
-
- Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
- Pifithrin-alpha (cyclic) . HBr
- 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole
- Pifithrin-2
- Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
- Pifithrin-β (QB-102 and Cyclic-Pifithrin-α)
- 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole
- CAS:
- 60477-34-1
- MF:
- C16H16N2S
- MW:
- 268.38
- Mol File:
- 60477-34-1.mol
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CYCLIC-PIFITHRIN-ALPHA Chemical Properties
- Melting point:
- 266.4-267.3 °C(lit.)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 20 mg/mL
- form
- White solid
- pka
- 6.75±0.20(Predicted)
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CYCLIC-PIFITHRIN-ALPHA Usage And Synthesis
Definition
ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.
General Description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
CYCLIC-PIFITHRIN-ALPHASupplier
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
MedChemexpress LLC
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- 021-58955995
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Shanghai Tauto Biotech Co., Ltd.
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- 021-51320588
- tauto@tautobiotech.com
Sigma-Aldrich
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- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com