Basic information Safety Supplier Related

MUCONOMYCIN A

Basic information Safety Supplier Related

MUCONOMYCIN A Basic information

Product Name:
MUCONOMYCIN A
Synonyms:
  • spiro(16,18-methano-1h,3h,23h-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyra
  • vera
  • Verrucarin
  • Muconomycin A, NSC 126728
  • verrucarin A from myrothecium sp
  • NSC 126728
  • MUCONOMYCIN A
  • VERRUCARIN A
CAS:
3148-09-2
MF:
C27H34O9
MW:
502.55
Mol File:
3148-09-2.mol
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MUCONOMYCIN A Chemical Properties

Melting point:
>360° (dec)
alpha 
D23 +206° (c = 1.012 in chloroform)
Boiling point:
512.66°C (rough estimate)
Density 
1.1922 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
−20°C
solubility 
Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form 
A solid
pka
12.76±0.70(Predicted)
color 
White to light yellow
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
WH1314900
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2941900000
Toxicity
LD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin)

MSDS

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MUCONOMYCIN A Usage And Synthesis

Uses

Verrucarin A from Myrothecium sp has been used:

  • as a translation initiation inhibitor in P. falciparum W2 strain
  • as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
  • to test its cytotoxicity in renal cell carcinoma cells

Definition

ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.

General Description

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.

Biochem/physiol Actions

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells

MUCONOMYCIN ASupplier

Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com