MUCONOMYCIN A
MUCONOMYCIN A Basic information
- Product Name:
- MUCONOMYCIN A
- Synonyms:
-
- spiro(16,18-methano-1h,3h,23h-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyra
- vera
- Verrucarin
- Muconomycin A, NSC 126728
- verrucarin A from myrothecium sp
- NSC 126728
- MUCONOMYCIN A
- VERRUCARIN A
- CAS:
- 3148-09-2
- MF:
- C27H34O9
- MW:
- 502.55
- Mol File:
- 3148-09-2.mol
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MUCONOMYCIN A Chemical Properties
- Melting point:
- >360° (dec)
- alpha
- D23 +206° (c = 1.012 in chloroform)
- Boiling point:
- 512.66°C (rough estimate)
- Density
- 1.1922 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- −20°C
- solubility
- Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
- form
- A solid
- pka
- 12.76±0.70(Predicted)
- color
- White to light yellow
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Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 1
- WGK Germany
- 3
- RTECS
- WH1314900
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2941900000
- Toxicity
- LD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin)
MSDS
- Language:English Provider:SigmaAldrich
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MUCONOMYCIN A Usage And Synthesis
Uses
Verrucarin A from Myrothecium sp has been used:
- as a translation initiation inhibitor in P. falciparum W2 strain
- as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
- to test its cytotoxicity in renal cell carcinoma cells
Definition
ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
General Description
Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
Biochem/physiol Actions
Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
MUCONOMYCIN ASupplier
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
- Tel
- meitaochem@126.com
- meitaochem@126.com
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MUCONOMYCIN A(3148-09-2)Related Product Information
- 2-Ethylhexyl acrylate
- MUCONOMYCIN A
- 2-BUTYL-2-ETHYL-1,3-PROPANEDIOL
- 1,2-EPOXY-3-METHYLBUTANE
- 1,2-EPOXYDECANE
- ISOOCTYL ACRYLATE
- 2-CYCLOHEXEN-1-OL
- LACTIC ACID ISOAMYL ESTER
- (S)-(-)-1,2-Epoxybutane
- FEMA 3506
- Ethyl L(-)-lactate
- ISOBUTYL LACTATE
- (R)-(+)-1,2-Epoxybutane
- 2-TERT-BUTYLPROPANE-1,3-DIOL
- 3-Cyclohexene-1-methanol
- 1,3-BUTADIENE-1-CARBOXYLIC ACID METHYL ESTER
- GLYCIDYL ISOBUTYL ETHER
- (S)-1,2-EPOXYPENTANE