GSK-626616
GSK-626616 Basic information
- Product Name:
- GSK-626616
- Synonyms:
-
- (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
- GSK-626616
- 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-
- GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- CAS:
- 1025821-33-3
- MF:
- C18H10Cl2N4OS
- MW:
- 401.27
- Mol File:
- 1025821-33-3.mol
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GSK-626616 Chemical Properties
- Melting point:
- 281 - 282oC
- Boiling point:
- 574.8±60.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly)
- pka
- -0.94±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
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GSK-626616 Usage And Synthesis
Uses
GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
storage
Store at +4°C
GSK-626616Supplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 021-2022843681 15618226720
- chaolaichem@foxmail.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com