Basic information Safety Supplier Related

GSK-626616

Basic information Safety Supplier Related

GSK-626616 Basic information

Product Name:
GSK-626616
Synonyms:
  • (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
  • GSK-626616
  • 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-
  • GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
  • (Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one
CAS:
1025821-33-3
MF:
C18H10Cl2N4OS
MW:
401.27
Mol File:
1025821-33-3.mol
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GSK-626616 Chemical Properties

Melting point:
281 - 282oC
Boiling point:
574.8±60.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly)
pka
-0.94±0.20(Predicted)
form 
Solid
color 
Pale Yellow to Light Yellow
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GSK-626616 Usage And Synthesis

Uses

GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.

storage

Store at +4°C

GSK-626616Supplier

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Email
lucy@atkchemical.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com