ChemicalBook > Product Catalog > API > Antibiotics > Other antibiotic Drugs > 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Basic information
- Product Name:
- 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
- Synonyms:
-
- ORMETHOPRIM
- ORMETOPRIM
- ORMETOPRIN
- OMP
- 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
- L-Ascorbic Phosphate Magnesium
- 2,4-DiaMino-5-92-Methyl-4,5- diMethoxybenzyl)pyriMidine
- DiaMino-5-(6-Methylveratryl)pyriMidine
- CAS:
- 6981-18-6
- MF:
- C14H18N4O2
- MW:
- 274.32
- EINECS:
- 230-246-6
- Product Categories:
-
- Active Pharmaceutical Ingredients
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 6981-18-6.mol
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties
- Melting point:
- 231.0 to 235.0 °C
- Boiling point:
- 521.5±60.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 7.11±0.10(Predicted)
- color
- Off-White
- Water Solubility
- Water: Insoluble
- λmax
- 287nm(CHCl3)(lit.)
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 6981-18-6(CAS DataBase Reference)
- EPA Substance Registry System
- Ormetoprim (6981-18-6)
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Safety Information
- Safety Statements
- 24/25
- HS Code
- 29333990
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Usage And Synthesis
Uses
It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidineSupplier
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine(6981-18-6)Related Product Information
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- Diaveridine
- 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine
- 5-ETHYL-2-PYRIMIDINAMINE
- 2,4-Diamino-5-(4-methoxybenzyl)pyrimidine
- 2,4-Diamino-5-(3-methoxybenzyl)pyrimidine
- 5-Benzyl-2,4-diaminopyrimidine
- 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine