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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

Basic information Safety Supplier Related

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Basic information

Product Name:
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
Synonyms:
  • ORMETHOPRIM
  • ORMETOPRIM
  • ORMETOPRIN
  • OMP
  • 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
  • L-Ascorbic Phosphate Magnesium
  • 2,4-DiaMino-5-92-Methyl-4,5- diMethoxybenzyl)pyriMidine
  • DiaMino-5-(6-Methylveratryl)pyriMidine
CAS:
6981-18-6
MF:
C14H18N4O2
MW:
274.32
EINECS:
230-246-6
Product Categories:
  • Active Pharmaceutical Ingredients
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
6981-18-6.mol
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties

Melting point:
231.0 to 235.0 °C
Boiling point:
521.5±60.0 °C(Predicted)
Density 
1.223±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
7.11±0.10(Predicted)
λmax
287nm(CHCl3)(lit.)
CAS DataBase Reference
6981-18-6(CAS DataBase Reference)
EPA Substance Registry System
Ormetoprim (6981-18-6)
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Safety Information

Safety Statements 
24/25
HS Code 
29333990
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Usage And Synthesis

Uses

It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029

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