PIRIBEDIL HYDROCHLORIDE
PIRIBEDIL HYDROCHLORIDE Basic information
- Product Name:
- PIRIBEDIL HYDROCHLORIDE
- Synonyms:
-
- 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidinedihydrochloride
- Piribedil dihydrochloride
- 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-pyrimidinmonohydrochlor
- 2-(4-piperonyl-1-piperazinyl)pyrimidinehydrochloride
- 2-(4-piperonyl-1-piperazinyl)-pyrimidinhydrochloride
- PIRIBEDIL HYDROCHLORIDE
- PiribedilHCl
- 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINE HYDROCHLORIDE
- CAS:
- 78213-63-5
- MF:
- C16H19ClN4O2
- MW:
- 334.8
- Product Categories:
-
- Dopamine receptor
- Mol File:
- 78213-63-5.mol
PIRIBEDIL HYDROCHLORIDE Chemical Properties
- storage temp.
- Store at RT
PIRIBEDIL HYDROCHLORIDE Usage And Synthesis
Uses
Piribedil dihydrochloride is a useful dopaminergic for biological research purposes.
Biological Activity
A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D 3 subtype, for which it has 20 times higher affinity than for D 2 , and possesses no significant affinity for D 1 ? receptors.
in vivo
Piribedil hydrochloride (intraperitoneal injection, 5, 15, 40 mg/kg ) alleviates the L-DOPA-induced dyskinesias in rats model of Parkinson’s disease[2].
Piribedil hydrochloride (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets[3].
Piribedil hydrochloride (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts[4].
| Animal Model: | Rat model of Parkinson’s disease[2] |
| Dosage: | 5, 15, 40 mg/kg |
| Administration: | Intraperitoneal injection, administered 5 min before administration of L-DOPA. |
| Result: | Reduced turning behaviour and AD (axial dystonia), OD (orolingual dyskinesia) and FD (forelimb dyskinesia) at 5 and 40 mg/kg. Increased LD (locomotive dyskinesias) at the 40 mg/kg. |
| Animal Model: | Adult common marmosets[3] |
| Dosage: | 4-5 mg/kg |
| Administration: | Oral gavage, daily for 2 weeks |
| Result: | Increased vigilance and alertness and reversed the downregulation of preprotachykinin mRNA induced by MPTP in rostral and caudal striatum. |
IC 50
D2 Receptor; D3 Receptor
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