(-)-3,4-Dihydroxynorephedrine
(-)-3,4-Dihydroxynorephedrine Basic information
- Product Name:
- (-)-3,4-Dihydroxynorephedrine
- Synonyms:
-
- 4-[2-AMINO-1-HYDROXYPROPYL]-1,2-BENZENEDIOL
- (-)3,4-DIHYDROXYNOREPHEDRINE
- (-)-3,4-DIHYDROXYNOREPHREDRINE
- CORBADRINE
- LEVONORDEFRIN
- Dihydroxyphenylpropanolamine
- Dioxynorepinephrine
- Isoadrenaline
- CAS:
- 829-74-3
- MF:
- C9H13NO3
- MW:
- 183.2
- Product Categories:
-
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 829-74-3.mol
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(-)-3,4-Dihydroxynorephedrine Chemical Properties
- Melting point:
- 212-215°C dec.
- Boiling point:
- 431.6±40.0 °C(Predicted)
- alpha
- D25 -31.0° (c = 0.5 in 0.01N HCl)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 9.59±0.10(Predicted)
- form
- powder
- color
- white to light brown
- Merck
- 13,6725
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
- InChIKey
- GEFQWZLICWMTKF-CDUCUWFYSA-N
- SMILES
- C[C@H](N)[C@H](O)c1ccc(O)c(O)c1
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 3
- HS Code
- 2922504500
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials - Hazard Classifications
- Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 - Toxicity
- LD50 in mice (mg/kg): 12.6 i.v. (Luduena)
MSDS
- Language:English Provider:SigmaAldrich
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(-)-3,4-Dihydroxynorephedrine Usage And Synthesis
Chemical Properties
White Powder
Uses
A vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics
Uses
Vasoconstrictor;Adrenergic receptor agonist
Definition
ChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant.
brand name
Neo-Cobefrin (Cook-Waite).
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