Safety Information

Hazard Codes 

F,C

Risk Statements 

63-14/15-34-62

Safety Statements 

16-26-36/37/39-43-45

RIDADR 

UN 3131 8(4.3) / PGII

WGK Germany 

3

LITHIUM TETRAMETHYLPIPERIDIDE Usage And Synthesis

Uses

Lithium 2,2,6,6-tetramethylpiperidide is a strong base and can be used:

• For the synthesis of enamines from terminal epoxides through trans-α-lithiated epoxide as an intermediate.
• For ortholithiation of arenes such as 1,3-bis(trifluoromethyl)benzene, 4,4-dimethyl-2-phenyl-2-oxazoline, 1,4-bis(trifluoromethyl)benzene and 1,3-dimethoxybenzene.
• In combination with Lewis donor ligand, N,N,N′,N′-tetramethylethylenediamine (TMEDA) for deprotonative metalation of methoxy-substituted arenes.{21]

LITHIUM TETRAMETHYLPIPERIDIDE(38227-87-1)Related Product Information

• 2,2,6,6-Tetramethylpiperidine
• 2,2,6,6-tetramethyl-4-piperidinol
• 2,2,6,6-Tetramethylpiperidinooxy
• 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex
• 2,2,6,6-Tetramethylpiperidinylzinc chloride lithium chloride complex solution, 1.0 M in THF
• Triacetonamine
• 2,2,6,6-Tetramethyl-3,5-heptanedione
• Lithium amide
• LITHIUM DIMETHYLAMIDE
• LITHIUM TETRAMETHYLPIPERIDIDE
• Lithium diisopropylamide
• 2,2-dimethylpiperidine
• LITHIUM DIETHYLAMIDE