3'-Deoxycytidine Chemical Properties

Melting point:

230-232 °C

Boiling point:

497.6±55.0 °C(Predicted)

Density 

1.73±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.01±0.60(Predicted)

form 

Solid

color 

White to light yellow

InChI

InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-6(14)3-5(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

InChIKey

ZHHOTKZTEUZTHX-SHYZEUOFSA-N

SMILES

OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)C1

Safety Information

RTECS 

HA3830000

HS Code 

29389090

3'-Deoxycytidine Usage And Synthesis

Uses

3'-Deoxycytidine is an inhibitor of nucleolar RNA synthesis but does not affect the appearance of mRNA. Displayed inhibitory properties against the replication of hepatitis C virus-like RNA template.

Biological Activity

3'-Deoxycytidine is a pyrimidine analog of cordycepin. The structures of cordycepin and 3'-deoxycytidine resemble adenosine and cytidine except for the altered 3' position in the ribose moiety, where hydrogen is substituted for the hydroxyl group. 3'-deoxycytidine affects similar to that of cordycepin on nucleolar RNA formation and has approximately the same level of activity as the adenosine analog. 3'-deoxycytidine, like cordycepin, enters cells and is phosphorylated by the appropriate enzymes. 3'-Deoxycytidine shares with cordycepin the ability to inhibit nucleolar RNA synthesis, but it does not affect the appearance of mRNA. Neither compound affects heterogeneous nuclear RNA (HnRNA)[1].

References

[1] Herbert T. Abelson, Sheldon Penman. “Messenger RNA formation: Resistance to inhibition by 3′-deoxycytidine.” Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 277 1 (1972): Pages 129-133.

3'-Deoxycytidine(7057-33-2)Related Product Information

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• CYTIDINE SULFATE
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• Cytidine 5’-monophosphate
• N4-Benzoylcytidine
• (+)-3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)cytidine
• 5-METHYLCYTIDINE
• CYTIDINE 3'-MONOPHOSPHATE
• N4-Acetylcytidine
• CYTIDINE 2'-MONOPHOSPHATE
• N4-BZ-2'-DEOXYCYTIDINE
• DMT-dC(bz) Phosphoramidite
• N4-BENZOYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE,n(4)-benzoyl-5'-o-(p,p'-dimethoxytrityl)-2'-deoxycytidine
• N-Acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine
• 2'-Deoxycytidine
• CCMP SODIUM SALT