4-METHOXYPHENYLACETAMIDE Chemical Properties

Melting point:

182-184°C

Boiling point:

354.7±25.0 °C(Predicted)

Density 

1.123±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

16.37±0.40(Predicted)

color 

White to Off-White

BRN 

2088040

CAS DataBase Reference

6343-93-7(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

HS Code 

2924297099

MSDS

• Language:English Provider:ALFA

4-METHOXYPHENYLACETAMIDE Usage And Synthesis

Uses

4-Methoxyphenylacetamide is a useful reagent in the preparation of novel pyrrolidone-??based derivatives as potential p53-??MDM2 inhibitors for use as potential antitumor agents.

Synthesis

General procedure for the synthesis of 4-methoxybenzeneacetamide from p-methoxybenzeneacetonitrile: Ni NPs/HT catalyst (0.05 g) was added to a thick-walled pressure tube, followed by water (4 ml) and p-methoxybenzeneacetonitrile (1 mmol). The reaction mixture was placed in an oil bath at 120 °C and stirred vigorously. The reaction process was monitored by TLC analysis. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate and subsequently filtered to remove the catalyst. The filtrate was cooled to 0 °C to allow white crystals to precipitate. The crystalline product was collected by simple filtration and dried under vacuum at room temperature to give analytically pure 4-methoxyphenylacetamide. If the product did not precipitate, the reaction mixture was extracted with ethyl acetate followed by purification by silica gel column chromatography to finally obtain 4-methoxyphenylacetamide.

References

[1] Synthesis, 1989, # 12, p. 949 - 951
[2] RSC Advances, 2015, vol. 5, # 9, p. 6365 - 6371
[3] Zeitschrift fur Chemie, 1980, vol. 20, # 10, p. 380 - 380
[4] Catalysis Communications, 2012, vol. 29, p. 109 - 113
[5] Green Chemistry, 2014, vol. 16, # 4, p. 2136 - 2141

4-METHOXYPHENYLACETAMIDE(6343-93-7)Related Product Information

• (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
• oxyphenisatine di(acetate)
• S(-)-ATENOLOL
• Atenolol
• (4-BUTOXYPHENYL)ACETAMIDE
• 2-[4-(2,3-EPOXYPROPOXY)PHENYL]ACETAMIDE
• Bufexamac
• ETHYL 3-HYDROXY-4,6-DIMETHOXY-2-OXOINDOLINE-3-CARBOXYLATE
• 3,4-DIMETHOXYPHENYLACETIC ACID HYDRAZIDE
• 4-Acetylamino-2-(diethylamino)anisole
• 4-Acetylamino-2-(bis(2-hydroxyethyl)amino)anisole
• 2',5'-DIMETHOXYACETANILIDE
• 4'-(Difluoromethoxy)acetanilide
• N-[3-[(2-Cyanoethyl)ethylamino]-4-methoxyphenyl]acetamide
• N-[3-[(2-Cyanoethyl)amino]-4-methoxyphenyl]acetamide
• 4-Acetylamino-2-(diallylamino)anisole
• 3'-Amino-4'-methoxyacetanilide
• 3-(N,N-Diacetoxyethyl)amino-4-methoxyacetanilide