3-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE Chemical Properties

Melting point:

156-158 °C

Boiling point:

367.4±44.0 °C(Predicted)

Density 

1.273±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.12±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

3-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE Usage And Synthesis

Synthesis

Step 2: N,N-dimethyl-3-nitrobenzenesulfonamide (850 mg, 3.7 mmol) was dissolved in methanol (20 mL). Wet Pd/C catalyst (85 mg) was added to the solution. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was evaporated under reduced pressure to afford 3-amino-N,N-dimethylbenzenesulfonamide (600 mg, 80% yield) as a white solid.LCMS (Method B): 0.48 [M + H]+ = 201.1.

References

[1] Patent: WO2015/172203, 2015, A1. Location in patent: Page/Page column 84
[2] Patent: US6503949, 2003, B1
[3] Patent: WO2009/66084, 2009, A1. Location in patent: Page/Page column 107-108
[4] Patent: EP1183229, 2005, B1. Location in patent: Page/Page column 153
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 1, p. 94 - 97

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