4'-CHLORODIAZEPAM CAS#: 14439-61-3

4'-CHLORODIAZEPAM Basic information

Product Name:

4'-CHLORODIAZEPAM

Synonyms:

7-Chloro-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
Aids080743
Aids-080743
7-chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2h-1,4-benzodiazepin-2-one
7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
chlorodiazepam

CAS:

14439-61-3

MF:

C16H12Cl2N2O

MW:

319.19

Mol File:

14439-61-3.mol

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4'-CHLORODIAZEPAM Chemical Properties

Melting point:: 160-163 °C
Boiling point:: 517.1±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: ethanol: 17 mg/mL
form: Off-white powder
pka: 3.08±0.10(Predicted)
color: White to light yellow
BRN: 685202

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Safety Information

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-24/25
RIDADR: 2811
WGK Germany: 3
RTECS: DF0500000
F: 10
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 14439-61-3(Hazardous Substances Data)

MSDS

Language:English Provider:SigmaAldrich

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4'-CHLORODIAZEPAM Usage And Synthesis

Uses

4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.

Biochem/physiol Actions

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

4'-CHLORODIAZEPAMSupplier

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