Benperidol Chemical Properties

Melting point:

170-171.8°

Boiling point:

230.3°C (rough estimate)

Density 

1.1876 (estimate)

storage temp. 

Store at -20°C

solubility 

Practically insoluble in water, freely soluble in dimethylformamide, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).

pka

12.04±0.30(Predicted)

form 

Solid

color 

White to off-white

CAS DataBase Reference

2062-84-2(CAS DataBase Reference)

NIST Chemistry Reference

Benperidol(2062-84-2)

Benperidol Usage And Synthesis

Chemical Properties

White or almost white powder.

Originator

Frenactil,Clin-Comar-Byla,France,1965

Uses

Antipsychotic.

Definition

ChEBI: 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one is an aromatic ketone.

Manufacturing Process

A mixture of 3.4 parts of γ-chloro-4-fluorobutyrophenone, 4 parts of 1-(4- piperidyl)-2-benzimidazolinone hydrochloride, 6 parts of sodium carbonate and 0.1 part of potassium iodide in 176 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours. The reaction mixture is cooled and 120 parts of water is added. The separated organic layer is dried over magnesium sulfate and the solvent is evaporated to leave an oily residue which is dissolved in dilute hydrochloric acid and boiled. The acidic solution is filtered and cooled at room temperature whereupon there crystallizes from solution 1-(1-[γ-(4- fluorobenzoyl)propyl] -4-piperidyl)-2-benzimidazolinone hydrochloride hydrate melting at about 134°-142°C.

Therapeutic Function

Tranquilizer

Benperidol(2062-84-2)Related Product Information

• Haloperidol
• tert-Butylchlorodiphenylsilane
• DROPERIDOL
• Penfluridol
• Diphenoxylate
• Benzimidazole
• Lidocaine hydrochloride
• Lidocaine
• Alkyl benzimidazole
• benzimidazolone
• 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE
• 1-(2-PROPYL)-2-BENZIMIDAZOLIDINONE
• Benperidol