N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties

Melting point:

256-257°C

storage temp. 

−20°C

solubility 

DMSO: ≥15 mg/mL

form 

crystalline

color 

Pale Yellow

Safety Information

WGK Germany 

3

MSDS

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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Usage And Synthesis

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

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