OSELTAMIVIR ACID Chemical Properties

Melting point:

183-185°C

Boiling point:

508.7±50.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

≥14.2 mg/mL in DMSO; ≥46.1 mg/mL in H2O with gentle warming; ≥97 mg/mL in EtOH with gentle warming

pka

4.13±0.60(Predicted)

form 

Solid

color 

White to off-white

EPA Substance Registry System

1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, (3R,4R,5S)- (187227-45-8)

Safety Information

HS Code 

9999999999

OSELTAMIVIR ACID Usage And Synthesis

Description

Oseltamivir (GS-4104) is an antiviral prodrug targeted against the influenza viruses. Oseltamivir acid is the active metabolite of oseltamivir. It acts as an inhibitor of influenza neuraminidases A and B (IC₅₀ = 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release.

Chemical Properties

White Solid

Uses

Oseltamivir Acid (Oseltamivir EP Impurity C) is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.

Uses

Oseltamivir Acid is a metabolite of Oseltamivir (O701000).

Definition

ChEBI: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). A antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.

References

[1] enguang feng, deju ye, jian li, dengyou zhang, jinfang wang, fei zhao, rolf hilgenfeld, mingyue zheng, hualiang jiang and hong liu. recent advances in neuraminidase inhibitor development as anti-influenza drugs. chem med chem 2012, 7: 1527 – 1536.
[2] tom jefferson reviewer, mark jones, peter doshi, elizabeth a spencer, igho onakpoya, carl j heneghan. oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comment. bmj. 2014, 348: g2545.
[3] rashmi dixit, gulam khandaker, scott ilgoutz, harunor rashid and robert booy. emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic. infectious disorders – drug targets. 2013, 13 (1): 34-45.

OSELTAMIVIR ACID(187227-45-8)Related Product Information

• 3-Des(1-ethylpropoxy)-3-(1-Methylpropoxy) OseltaMivir
• 4-N-Desacetyl-5-N-acetyl OseltaMivir
• OseltaMivir IMpurity D
• OseltaMivir Acid Methyl Ester
• Oseltamivir EP Impurity A
• Oseltamivir EP Impurity E HCl
• ent-OseltaMivir Phosphate
• (3R,4R,5R)-3-(1-Ethylpropoxy)-4-hydroxy-5-[(Methylsulfonyl)oxy]-1-cyclohexene-1-carboxylic Acid Ethyl Ester
• Oseltamivir Impurity 17
• Oseltamivir phosphate
• Oseltamivir
• OSELTAMIVIR MONO HYDROCHLORIDE
• OSELTAMIVIR ACID
• OSELTAMIVIR-D3 PHOSPHATE
• OSELTAMIVIR ACID-D3
• OSELTAMIVIR, [3H]-
• OSELTAMIVIR CITRATE