RAN antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Hamster;Monkey;Bovine

Background

Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport. During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation. In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle.

References

[1] Quimby, B.B. and Dasso, M. (2003) Curr. Opin. Cell Biol. 15, 338-344.
[2] Hetzer, M. et al. (2002) Nat. Cell Biol. 4, 177-184.
[3] Yamaguchi, R. and Newport, J. (2003) Cell 113, 115-125.

RAN antibody()Related Product Information

• HOXC8 antibody
• Smurf1 Antibody
• ALDH6A1 antibody
• STAT5A Antibody
• PBK antibody
• NFKB2 antibody
• Mouse Monoclonal SLINGSHOT-1L Antibody
• CDH11 antibody
• GSK3B antibody
• NT5E antibody