TRPC3 (D4P5S) Rabbit mAb Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Transient Receptor Potential Canonical 3 belongs to the superfamily of TRP cation channels. The TRPC subfamily is a group of calcium-permeable cation channels that mediates the increase in intracellular [Ca2+] following activation by G-protein-coupled receptors or receptor tyrosine kinases. TRPC3 is mainly expressed in the brain and various other tissues, though at a much lower level. In the brain, TRPC3 is involved in BDNF-induced axonal growth cone plasticity, dendritic spine formation, and neuronal survival. It is also required for synaptic transmission and motor coordination. Outside of the central nervous system, TRPC3 also exerts other important biological functions such as regulating cardiac and vascular contractility, maintaining Ca2+ homeostasis in primary T cells and endothelial cells. TRPC3 is activated by diacylglycerol and Inositol 1,4,5-trisphosphate. It is also activated by internal calcium store depletion and regulates mitochondrial calcium uptake.

References

[1] Montell, C. (2005) Sci STKE 2005, re3.
[2] Riccio, A. et al. (2002) Brain Res Mol Brain Res 109, 95-104.
[3] Li, H.S. et al. (1999) Neuron 24, 261-73.
[4] Li, Y. et al. (2005) Nature 434, 894-8.
[5] Amaral, M.D. and Pozzo-Miller, L. (2007) J Neurosci 27, 5179-89.
[6] Jia, Y. et al. (2007) Nat Neurosci 10, 559-67.
[7] Hartmann, J. et al. (2008) Neuron 59, 392-8.
[8] Nilius, B. et al. (2003) Endothelium 10, 5-15.
[9] Yeon, S.I. et al. (2014) PLoS One 9, e110413.
[10] Wenning, A.S. et al. (2011) Biochim Biophys Acta 1813, 412-23.

TRPC3 (D4P5S) Rabbit mAb()Related Product Information

• TRPA1 Ab
• TRP2 (C-9)
• TRPC4 shRNA (m) Lentiviral Particles
• TRPV1 (Human) Recombinant Protein (Q01)
• TRP2 (B-7)
• TRPM2 BLOCKING PEPTIDE
• TRPC3 (C-5) HRP
• TRPM2 Ab
• TRPC3 (C-5)
• TRP1 (G-9)
• TRPV4 antibody
• TRPC1 (E-6)
• TRPV4 blocking peptide
• TRPC6 (B-10)
• TRP2 (E-10)
• TRP1 (TA99)