4-Chloro-3-fluorobenzyl Bromide Chemical Properties

Melting point:

30-33℃

Boiling point:

227.1±25.0 °C(Predicted)

Density 

1.654±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to lump

color 

White to Light yellow to Light orange

Sensitive 

Lachrymatory

CAS DataBase Reference

206362-80-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3261

Hazard Note 

Corrosive/Lachrymatory

HazardClass 

CORROSIVE

HazardClass 

8

PackingGroup 

Ⅱ

HS Code 

29039990

4-Chloro-3-fluorobenzyl Bromide Usage And Synthesis

Chemical Properties

White solid

Synthesis

Step 1: Bromine (16.5 g, 0.103 mol) was added dropwise to a solution of triphenylphosphine (27.8 g, 0.103 mol) in dichloromethane (200 mL) at 0°C while stirring. After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. Subsequently, 4-chloro-3-fluorobenzyl alcohol (15.8 g, 0.098 mol) was added and the reaction mixture was stirred for 30 minutes. Upon completion of the reaction, the reaction was quenched with ethanol and the mixture was poured into saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography afforded 4-(bromomethyl)-1-chloro-2-fluorobenzene (18.6 g, 85% yield).1H-NMR (400 MHz, CDCl3): δ = 7.27 (t, J = 7.9 Hz, 1H), 7.10 (dd, J = 7.9 Hz, 2.1 Hz, 1H), 7.04-6.99 (m, 1H). 4.32 (s, 2H).

References

[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0185

4-Chloro-3-fluorobenzyl Bromide(206362-80-3)Related Product Information

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