1-Hydroxy anthraquinone
1-Hydroxy anthraquinone Basic information
- Product Name:
- 1-Hydroxy anthraquinone
- Synonyms:
-
- 4-HYDROXYANTHRAQUINONE
- 1-hydroxy-9,10-anthracenedione
- 1-HYDROXYANTHRAQUINONE
- erythroxyanthraquinone
- 1-hydroxyanthracene-9,10-dione
- NISTC129431
- 10-Anthracenedione,1-hydroxy-9
- 1-hydroxy-10-anthracenedione
- CAS:
- 129-43-1
- MF:
- C14H8O3
- MW:
- 224.21
- EINECS:
- 204-946-7
- Product Categories:
-
- Anthraquinones
- Hydroxyanthraquinones
- Classes of Metal Compounds
- Li (Lithium) Compounds
- Typical Metal Compounds
- Mol File:
- 129-43-1.mol
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1-Hydroxy anthraquinone Chemical Properties
- Melting point:
- 194°C
- Boiling point:
- 325.61°C (rough estimate)
- Density
- 1.2337 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform: 30 mg/ml
- form
- powder to crystal
- pka
- 7.15±0.20(Predicted)
- color
- Light yellow to Brown
- CAS DataBase Reference
- 129-43-1(CAS DataBase Reference)
- IARC
- 2B (Vol. 82) 2002
- NIST Chemistry Reference
- 9,10-Anthracenedione, 1-hydroxy-(129-43-1)
- EPA Substance Registry System
- 9,10-Anthracenedione, 1-hydroxy- (129-43-1)
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-40-36
- Safety Statements
- 26-36/37/39-45
- RTECS
- CB7178000
- HS Code
- 2914.69.9000
- Hazardous Substances Data
- 129-43-1(Hazardous Substances Data)
MSDS
- Language:English Provider:1-Hydroxy-9,10-anthracenedione
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1-Hydroxy anthraquinone Usage And Synthesis
Uses
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].
Definition
ChEBI: 1-hydroxyanthraquinone is a monohydroxyanthraquinone.
Synthesis Reference(s)
The Journal of Organic Chemistry, 55, p. 350, 1990 DOI: 10.1021/jo00288a062
in vivo
1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1].
| Animal Model: | Thirty rats[1]. |
| Dosage: | 1% HA in diet. |
| Administration: | Diet. |
| Result: | Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g). |
References
[1] H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. DOI:10.1093/carcin/11.5.799
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