N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Basic information
- Product Name:
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- Synonyms:
-
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- SB 228357
- N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
- N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
- 1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
- SB-228357,SB228357
- CAS:
- 181629-93-6
- MF:
- C22H17F4N3O2
- MW:
- 431.38
- Mol File:
- 181629-93-6.mol
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Chemical Properties
- Boiling point:
- 625.4±55.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ~8 mg/mL, soluble
- form
- solid
- pka
- 9.72±0.70(Predicted)
- color
- white
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Usage And Synthesis
Uses
SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
Definition
ChEBI: SB 228357 is an indolyl carboxylic acid.
Biological Activity
5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
storage
Store at RT
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE(181629-93-6)Related Product Information
- 6-METHYL-2,3-DIHYDRO-1H-INDOLE
- 3-Fluoro-5-methylaniline
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
- 3-Pyridin-3-ylaniline
- alpha,alpha,alpha-Trifluoro-o-cresol
- 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
- 4-Amino-2,5-dimethylphenol
- 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL
- 6-(Trifluoromethyl)indoline
- 2-(TRIFLUOROMETHYL)ANISOLE