N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Basic information
- Product Name:
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- Synonyms:
-
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- SB 228357
- N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
- N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
- 1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
- SB-228357,SB228357
- SB228357, 10 mM in DMSO
- N-(3-Fluoro-5-(pyridin-3-yl)phenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide
- CAS:
- 181629-93-6
- MF:
- C22H17F4N3O2
- MW:
- 431.38
- Mol File:
- 181629-93-6.mol
More
Less
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Chemical Properties
- Boiling point:
- 625.4±55.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ~8 mg/mL, soluble
- form
- solid
- pka
- 9.72±0.70(Predicted)
- color
- white
More
Less
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
More
Less
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Usage And Synthesis
Uses
SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
Definition
ChEBI: SB 228357 is an indolyl carboxylic acid.
Biological Activity
5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
in vivo
SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2].
| Animal Model: | Male Sprague Dawley rats (200-250?g) injected with Haloperidol[2] |
| Dosage: | 0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg |
| Administration: | Oral administration; for 90 minutes |
| Result: | Significantly reversed Haloperidol-induced catalepsy. |
IC 50
5-HT2A Receptor: 6.9 (pKi); 5-HT2C Receptor: 9 (pKi); 5-HT2B Receptor: 8 (pKi)
storage
Store at RT
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Shanghai Rechem science Co., Ltd.
- Tel
- 021-31433387 15618786686
- sales@rechemscience.com
More
Less
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE(181629-93-6)Related Product Information
- 6-METHYL-2,3-DIHYDRO-1H-INDOLE
- 3-Fluoro-5-methylaniline
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
- 3-Pyridin-3-ylaniline
- alpha,alpha,alpha-Trifluoro-o-cresol
- 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
- 4-Amino-2,5-dimethylphenol
- 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL
- 6-(Trifluoromethyl)indoline
- 2-(TRIFLUOROMETHYL)ANISOLE