2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Basic information
- Product Name:
- 2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
- Synonyms:
-
- (R,S)-2-Fluoro-3-oxo-3-phenyl-propionicacidethylester
- R,S-2-Fluoro-3-oxo-3-phenyl-propionicacidethylester
- 2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
- Ethyl 2-fluoro-3-oxo-3-phenylpropanoate
- Benzenepropanoic acid, α-fluoro-β-oxo-, ethyl ester
- Benzenepropanoic acid, α-fluoro-β-oxo-, ethyl ester
- CAS:
- 1479-22-7
- MF:
- C11H11FO3
- MW:
- 210.2
- Mol File:
- 1479-22-7.mol
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2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Chemical Properties
- Melting point:
- 33-35 °C
- Boiling point:
- 116°C 0,3mm
- Density
- 1.169±0.06 g/cm3(Predicted)
- pka
- 8.20±0.26(Predicted)
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Safety Information
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
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2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Usage And Synthesis
Uses
Ethyl 2-Benzoyl-2-fluoroacetate is used in the chemoselective preparation of α-chloro- and α-fluoro-β-keto esters by chlorination or fluorination with N-chlorosuccinimide or Selectfluor in the presence of titanium catalysts such as (cyclopentadienyl)titanium trichloride.
Synthesis Reference(s)
The Journal of Organic Chemistry, 56, p. 273, 1991 DOI: 10.1021/jo00001a052
Tetrahedron Letters, 37, p. 653, 1996 DOI: 10.1016/0040-4039(95)02224-4
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