Basic information Safety Supplier Related

2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER

Basic information Safety Supplier Related

2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Basic information

Product Name:
2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
Synonyms:
  • (R,S)-2-Fluoro-3-oxo-3-phenyl-propionicacidethylester
  • R,S-2-Fluoro-3-oxo-3-phenyl-propionicacidethylester
  • 2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
  • Ethyl 2-fluoro-3-oxo-3-phenylpropanoate
  • Benzenepropanoic acid, α-fluoro-β-oxo-, ethyl ester
  • Benzenepropanoic acid, α-fluoro-β-oxo-, ethyl ester
CAS:
1479-22-7
MF:
C11H11FO3
MW:
210.2
Mol File:
1479-22-7.mol
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2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Chemical Properties

Melting point:
33-35 °C
Boiling point:
116°C 0,3mm
Density 
1.169±0.06 g/cm3(Predicted)
pka
8.20±0.26(Predicted)
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Safety Information

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER Usage And Synthesis

Uses

Ethyl 2-Benzoyl-2-fluoroacetate is used in the chemoselective preparation of α-chloro- and α-fluoro-β-keto esters by chlorination or fluorination with N-chlorosuccinimide or Selectfluor in the presence of titanium catalysts such as (cyclopentadienyl)titanium trichloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 273, 1991 DOI: 10.1021/jo00001a052
Tetrahedron Letters, 37, p. 653, 1996 DOI: 10.1016/0040-4039(95)02224-4

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