ETHYL 2-FLUOROACETOACETATE Chemical Properties

Boiling point:

183 °C (lit.)

Density 

1.181 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.414(lit.)

Flash point:

194 °F

storage temp. 

Storage temp. 2-8°C

pka

9.25±0.46(Predicted)

form 

Liquid

color 

Clear colorless to pale yellow

InChI

InChI=1S/C6H9FO3/c1-3-10-6(9)5(7)4(2)8/h5H,3H2,1-2H3

InChIKey

SHTFQLHOTAJQRJ-UHFFFAOYSA-N

SMILES

C(OCC)(=O)C(F)C(=O)C

CAS DataBase Reference

1522-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29183000

MSDS

• Language:English Provider:SigmaAldrich

ETHYL 2-FLUOROACETOACETATE Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

Reactant for:

• Michael addition-induced cyclization reaction
• Asymmetric Mannich reaction
• Enantioselective organocatalytic conjugate addition

Synthesis Reference(s)

Tetrahedron, 54, p. 2867, 1998 DOI: 10.1016/S0040-4020(98)83023-8

General Description

Ethyl 2-fluoroacetoacetate is an α-fluorinated β-keto ester that can be prepared by the fluorination of ethyl acetoacetate.

ETHYL 2-FLUOROACETOACETATE(1522-41-4)Related Product Information

• Acetyl chloride
• Ethyl acetoacetate
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• ETHYL 2-FLUOROACETOACETATE
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• 2,2-DIFLUORO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER
• 2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
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