ETHYL 2-FLUOROACETOACETATE Chemical Properties

Boiling point:

183 °C (lit.)

Density 

1.181 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.414(lit.)

Flash point:

194 °F

form 

Liquid

pka

9.25±0.46(Predicted)

color 

Clear colorless to pale yellow

InChIKey

SHTFQLHOTAJQRJ-UHFFFAOYSA-N

CAS DataBase Reference

1522-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29183000

MSDS

• Language:English Provider:SigmaAldrich

ETHYL 2-FLUOROACETOACETATE Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

Reactant for:

• Michael addition-induced cyclization reaction
• Asymmetric Mannich reaction
• Enantioselective organocatalytic conjugate addition

Synthesis Reference(s)

Tetrahedron, 54, p. 2867, 1998 DOI: 10.1016/S0040-4020(98)83023-8

General Description

Ethyl 2-fluoroacetoacetate is an α-fluorinated β-keto ester that can be prepared by the fluorination of ethyl acetoacetate.

ETHYL 2-FLUOROACETOACETATE(1522-41-4)Related Product Information

• Acetyl chloride
• Ethyl acetoacetate
• Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
• ETHYL 2-FLUOROACETOACETATE
• ETHYL 2,2-DIFLUOROACETOACETATE
• Ethyl 2-fluoro-3-oxopentanoate
• Ethyl 4,4,4-trifluoroacetoacetate
• ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE
• Ethyl 2-chloro-4,4,4-trifluoroacetoacetate
• Ethyl 4,4-difluoro-3-oxobutanoate
• 2-BROMO-2-FLUORO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER
• 2-Fluoro-2-methyl-3-oxo-3-phenyl-propionic acid ethyl ester
• ETHYL-2,4,4,4-TETRAFLUOROACETOACETATE
• 2,2-DIFLUORO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER
• 2-FLUORO-3-OXO-3-PHENYLPROPIONIC ACID ETHYL ESTER
• ETHYL 4-FLUOROACETOACETATE