METHYLENE BLUE
METHYLENE BLUE Basic information
- Product Name:
- METHYLENE BLUE
- Synonyms:
-
- CI 52015
- CINO 52015
- METHYLENE BLUE HYDRATE
- METHYLENE BLUE FOR MICROSCOPY
- METHYLENE BLUE REDOX INDICATOR, REAG. PH . EUR.
- METHYLENE BLUE TRIHYDRATE MOLECULAR*BIOL OGY REAGENT
- METHYLENE BLUE EXTRA PURE
- MethyleneblueHydrat
- CAS:
- 122965-43-9
- MF:
- C16H20ClN3OS
- MW:
- 337.87
- EINECS:
- 602-909-3
- Product Categories:
-
- Analytical Reagents
- Microscopy Reagents
- Stains and Dyes
- Laser DyesStains and Dyes
- M
- Organic Electronics and Photonics
- Photonic and Optical Materials
- Stains&Dyes, A to
- Nitric Oxide and Cell Stress
- Nitric Oxide Metabolism
- Nitric Oxide Scavengers
- Nitric Oxide ScavengersCell Signaling Enzymes
- Indicators
- Redox Indicators
- Titration
- Mol File:
- 122965-43-9.mol
METHYLENE BLUE Chemical Properties
- Melting point:
- 190 °C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble4mg/4ml
- form
- Fine Crystalline Powder
- Colour Index
- 52015
- color
- Green
- Water Solubility
- Soluble in water, alcohol, acetic acid, glycerol and chloroform. Insoluble in ether.
- λmax
- 661 nm
- Merck
- 14,6060
- BRN
- 3599847
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
METHYLENE BLUE Usage And Synthesis
Chemical Properties
green fine crystalline powder
Uses
Methylene blue is used as a dye for a number of different staining procedures, such as Wright's stain and Jenner's stain. Since it is a temporary staining technique, methylene blue can also be used to examine RNA or DNA under the microscope or in a gel. I
Uses
Methylene blue is used as a dye in different staining procedures viz. Wright's stain and Jenner's stain. It also serves as an indicator and medicine. Further, it is used to examine RNA and DNA under the microscope or in a gel. It is widely used as a redox indicator in analytical chemistry. It acts as a photosensitizer utilized to generate singlet oxygen in order to make organic peroxides by a Diels-Alder reaction. It is also used in the sulfide analysis. It plays an important role in aquaculture to treat fungal infections.
General Description
Methylene Blue (MB) is a basic histological dye.
Biochem/physiol Actions
Methylene blue is used as a bacteriologic stain or dye and indicator. It mediates the inactivation of enveloped viruses in plasma, when exposed to visible light. It is an inhibitor of nitric oxide synthase and guanylate cyclase. It also plays a key role in medicine as an antimalarial agent, reducing agent in methemoglobinemia and inducer of apoptosis in cancer cells.
in vivo
Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition[1].
Methylene blue hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau[2].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior[3].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor[3].
| Animal Model: | Male NMRI mice[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Intraperitoneal injection; once, for 25 minutes |
| Result: | Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP). |
| Animal Model: | CaMKIIα-tTA transactivator mice[2] |
| Dosage: | 20 and 40 mg/kg |
| Administration: | Oral administration; daily, for 6 months |
| Result: | Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice. |
| Animal Model: | TBI-treated male BALB/c mice[3] |
| Dosage: | 2 mg/kg |
| Administration: | Intravenous injection; once, for 1 day |
| Result: | Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA. |
| Animal Model: | TBI-treated male BALB/c mice[3] |
| Dosage: | 2 mg/kg |
| Administration: | Intravenous injection; once, for 1 day |
| Result: | Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL-10 expression in microglia. |
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