(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone Chemical Properties

Boiling point:

467.2±55.0 °C(Predicted)

Density 

1.12

storage temp. 

2-8°C

solubility 

Dichloromethane, Ether, Ethyl Acetate, Methanol

form 

Oil

pka

-4.66±0.60(Predicted)

color 

Transparent

CAS DataBase Reference

149249-91-2(CAS DataBase Reference)

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone Usage And Synthesis

Uses

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is an intermedaite of 10-O-[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel (B207800), which is an impurity in the synthesis of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi''s sarcoma.

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone(149249-91-2)Related Product Information

• Phenyl salicylate
• Benzoyl peroxide
• Trimethoxyphenylsilane
• 4-Methyl-2-pentanone
• BENZOYL ISOCYANATE
• Benzoyl chloride
• Ethyltriphenylphosphonium bromide
• PHENYL VALERATE
• Diphenyl ether
• Phenyltriethoxysilane
• Docetaxel
• Docetaxel trihydrate
• PHENYL RESIN
• 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole
• BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID
• (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
• 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel
• 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID