4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE Chemical Properties

Melting point:

186-188 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))

Boiling point:

325.9±22.0 °C(Predicted)

Density 

1.531±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

11.58±0.40(Predicted)

color 

Off-white

Safety Information

HazardClass 

IRRITANT

HS Code 

2933599590

4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE Usage And Synthesis

Description

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is a purine analog that inhibits the growth of bacteria by binding to the enzyme DNA gyrase. It has been shown to be effective against staphylococcus and Mycobacterium tuberculosis.

Uses

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is a chlorinated pyrrolopyrimidine used in the preparation of compounds with antibacterial and antitumor activities.

Application

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine binds to the enzyme DNA gyrase and prevents it from breaking down the bacterial DNA. This drug also has antimycobacterial activity due to its ability to bind to the enzyme RNA polymerase.

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