2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Properties

Melting point:

58-60 °C(lit.)

Boiling point:

331.4±42.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

Water Solubility 

almost transparency in hot Water

solubility 

DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.2 mg/ml

form 

Crystalline Powder or Needles

color 

Red to orange

Sensitive 

Light Sensitive

BRN 

1640422

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents.

CAS DataBase Reference

605-94-7(CAS DataBase Reference)

NIST Chemistry Reference

2,5-Cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-(605-94-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

F 

8-10-21

HS Code 

29146990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,3-Dimethoxy-5-methyl-p-benzoquinone Usage And Synthesis

Chemical Properties

red or orange crystals or fibres

Uses

2,3-Dimethoxy-5-methyl-p-benzoquinone (Ubidecarenone EP Impurity A)

Definition

ChEBI: A derivative of benzoquinone carrying a 5-methyl substituent; and methoxy substituents at positions 2 and 3. The core structure of the ubiquinone group of compounds.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 16, p. 2343, 1968 DOI: 10.1248/cpb.16.2343
The Journal of Organic Chemistry, 53, p. 5453, 1988 DOI: 10.1021/jo00258a010

General Description

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀ or DMM) is present in all the cells including neural cells.

Biochem/physiol Actions

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.

Purification Methods

It crystallises in red needles from pet ether (b 40-60o) and sublimes at high vacuum at a bath temperature of 46-48o [Ashley et al. J Chem Soc 441 1938, UV in EtOH: Vischer J Chem Soc 815 1953, UV in cyclohexane: Morton et al. Helv Chim Acta 41 2343 1858, Aghoramurthy et al. Chem Ind (London) 1327 1954]. [Beilstein 8 IV 2721.]

2,3-Dimethoxy-5-methyl-p-benzoquinone(605-94-7)Related Product Information

• Methylparaben
• 1,4-Benzoquinone
• Diphenyldimethoxysilane
• Kresoxim-methyl
• Acetyl coenzyme A sodium salt
• Methyltrimethoxysilane
• Bensulfuron methyl
• Thiophanate-methyl
• 2,5-Dimethoxybenzo-1,4-quinone
• Methyl acrylate
• Coenzyme A
• Methyltriethoxysilane
• Coenzyme Q10
• Dimethyldimethoxysilane
• METHYL THIOPHENE-2-CARBOXYLATE
• 6-Thioguanine
• 1,1-Dimethoxyethane
• Diethoxydimethylsilane