N,N-DIMETHYL-M-TOLUIDINE Chemical Properties

Melting point:

-15 °C

Boiling point:

215 °C(lit.)

Density 

0.93 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.55(lit.)

Flash point:

185 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

pka

5.22±0.10(Predicted)

color 

Clear yellow

BRN 

1422766

CAS DataBase Reference

121-72-2(CAS DataBase Reference)

EPA Substance Registry System

Benzenamine, N,N,3-trimethyl- (121-72-2)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-33-52/53

Safety Statements 

28-36/37-45-61

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

2

RTECS 

XU5798000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29214300

Toxicity

LD50 intraperitoneal in mouse: 300mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N,N-DIMETHYL-M-TOLUIDINE Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

N,N,3-Trimethylaniline, is an building block used for the synthesis of more complex compounds, such as BTK (Bruton''s tyrosine kinase) inhibitor.

Uses

N,N-Dimethyl-m-toluidine may be used in chemical synthesis studies.

General Description

A clear colorless liquid with an aromatic odor. Density 0.932 g / cm3 (Lancaster) and insoluble in water. Hence floats on water. Toxic by skin absorption and inhalation. Flash point 185°F. May release toxic vapors when burned.

Air & Water Reactions

Tends to darken upon exposure to air. Insoluble in water.

Reactivity Profile

N,N-DIMETHYL-M-TOLUIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Purification Methods

Reflux it for 3hours with 2 molar equivalents of Ac2O, then fractionally distil it under reduced pressure. Alternatively, dry over BaO, distil and store it over KOH. The hydrochloride has m 176o (from EtOH) and the picrate has m 131o. Methods described for N,N-dimethylaniline are applicable. [Beilstein 12 H 857, 12 III 1953, 12 IV 1815.]

N,N-DIMETHYL-M-TOLUIDINE(121-72-2)Related Product Information

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