Methyl 1,2,4-triazole-3-carboxylate Chemical Properties

Melting point:

196-199 °C(lit.)

Boiling point:

283.9±23.0 °C(Predicted)

Density 

1.380±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

7.96±0.20(Predicted)

form 

Liquid

color 

Clear colorless to yellow

CAS DataBase Reference

4928-88-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl 1,2,4-triazole-3-carboxylate Usage And Synthesis

Uses

Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.

Chemical Properties

White solid

Uses

Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.

Uses

Methyl-1H-1,2,4-triazole-3-carboxylate (1,2,4-Triazole-3-methylcarboxylate) may be used in the preparation of 1H-1,2,4-triazole-3-carbohydrazide.
It may also be used in the synthesis of the following nucleoside analogues:

• 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta-[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
• methyl 4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altrohexopyranoside
• 1,5-anhydro-4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altro-hexitol

General Description

Methyl-1H-1,2,4-triazole-3-carboxylate can be synthesized from 5-amino-1,2,4-triazole-3-carboxylic acid via esterification with methanol. It is utilized as precursor for preparing the nucleoside analogue, Ribavirin. The crystal structure of methyl-1H-1,2,4-triazole-3-carboxylate has been analyzed.

Methyl 1,2,4-triazole-3-carboxylate (4928-88-5)Related Product Information

• Kresoxim-methyl
• Methylparaben
• RESMETHRIN
• Thiophanate-methyl
• Methyl acrylate
• 5-Methyl-1H-benzotriazole
• 1H-Benzotriazole
• Bensulfuron methyl
• Tolyltriazole
• 1,2,4-Triazole
• Methyl
• Parathion-methyl
• Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
• ethyl 5-amino-2H-1,2,4-triazole-3-carboxylate
• FENCHLORAZOL-ETHYL
• Methyl bromide
• Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate
• 1H-1,2,4-Triazole-3-carboxylic acid