METHOXYVERAPAMIL HYDROCHLORIDE
METHOXYVERAPAMIL HYDROCHLORIDE Basic information
- Product Name:
- METHOXYVERAPAMIL HYDROCHLORIDE
- Synonyms:
-
- (+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE
- VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE
- (+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE
- GALLOPAMIL
- D600
- D600, HCL
- D 600 HYDROCHLORIDE
- [3-cyano-3-(3,4,5-trimethoxyphenyl)hex-6-yl]-(5,6-dimethoxyphenethyl)methylammonium chloride
- CAS:
- 16662-46-7
- MF:
- C28H41ClN2O5
- MW:
- 521.09
- EINECS:
- 2407047
- Mol File:
- 16662-46-7.mol
METHOXYVERAPAMIL HYDROCHLORIDE Chemical Properties
- Melting point:
- 145-148°
- storage temp.
- Store at -20°C
- solubility
- DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
- form
- A crystalline solid
- color
- White to off-white
MSDS
- Language:English Provider:SigmaAldrich
METHOXYVERAPAMIL HYDROCHLORIDE Usage And Synthesis
Description
Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium channel blocker verapamil with a similar profile. It is useful in the treatment of angina and auricular arrhythmia.
Originator
Knoll (W. Germany)
Uses
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].
brand name
Benpredil;Corapamil;PROCORUM.
in vivo
Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].
| Animal Model: | Male Wistar rats weighing 290-370 g[3] |
| Dosage: | 0.2 mg/kg |
| Administration: | i.v.; 5 min |
| Result: | Markedly reduced VT and totally prevented VF. |
References
[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x
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METHOXYVERAPAMIL HYDROCHLORIDE(16662-46-7)Related Product Information
- 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile
- 3,5-DIMETHOXYPHENYLACETONITRILE
- (-)-METHOXYVERAPAMIL HYDROCHLORIDE
- (3-Methoxyphenyl)acetonitrile
- (3,4-DIHYDROXYPHENYL)ACETONITRILE
- 2-ETHYL-2-METHYLBUTYRONITRILE
- 2-ISOPROPYL-2-PHENYLACETONITRILE
- Devapamil
- Trimethylacetonitrile
- 3-HYDROXY-4-METHOXYPHENETHYLAMINE HYDROCHLORIDE
- Hordenine hydrochloride
- 3-tert-Butylphenol
- 5-TERT-BUTYLPYROGALLOL
- 2-PHENYLBUTYRONITRILE
- (3,4-Dimethoxyphenyl)acetonitrile
- 2-Ethyl-2-phenylbutyronitrile
- 3-Methylbutanenitrile
- (+/-)-METHOXYVERAPAMIL HYDROCHLORIDE (D6 00) (GALLOPAMIL)