METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Chemical Properties

Boiling point:

605.9±55.0 °C(Predicted)

Density 

1.068±0.06 g/cm3(Predicted)

solubility 

H₂O: soluble

pka

8.96±0.50(Predicted)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Usage And Synthesis

Uses

(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2].

References

[1] Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. DOI:10.1161/hh2001.098983
[2] Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. DOI:10.1111/j.1469-7793.1999.0315m.x

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