(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Basic information
- Product Name:
- (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- Synonyms:
-
- Dexverapamil
- (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
- Dexverapami
- Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI)
- Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-
- d-Verapamil
- (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride
- Dexverapamil Hydrochloride
- CAS:
- 38321-02-7
- MF:
- C27H38N2O4
- MW:
- 454.61
- EINECS:
- 253-878-4
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 38321-02-7.mol
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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Chemical Properties
- Melting point:
- 129-131°C
- Boiling point:
- 586.1±50.0 °C(Predicted)
- Density
- 1.058±0.06 g/cm3(Predicted)
- pka
- 8.97±0.50(Predicted)
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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells
Definition
ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrileSupplier
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
Clearsynth Labs Limited
- Tel
- +91-22-26355700
- info@clearsynth.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com
QUALITY CONTROL SOLUTIONS LTD.
- Tel
- 13670046396
- ORDERS@QCSRM.COM
Changzhou Bojia Biomedical Technology Co., Ltd.
- Tel
- 2122619822
- czbjpharma@126.com
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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile(38321-02-7)Related Product Information
- (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- 2-(4-Methoxyphenyl)-2-methylpropanenitrile
- Devapamil
- (+/-)-Verapamil hydrochloride
- METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
- R(+)-VERAPAMIL HYDROCHLORIDE
- 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile
- 4-HYDROXY-3-METHOXYPHENYLACETONITRILE
- Verapamil
- (3,4-Dimethoxyphenyl)acetonitrile
- Benzeneacetonitrile
- Valeronitrile
- P-O-DESMETHYL VERAPAMIL
- 1-(3,4-DIMETHOXYPHENYL)-VALERONITRILE
- NORVERAPAMIL
- Emopamil
- 2-(3-METHOXYPHENYL)-2-METHYLPROPANENITRILE
- 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE