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Cholesteryl sodium sulfate

Basic information Safety Supplier Related

Cholesteryl sodium sulfate Basic information

Product Name:
Cholesteryl sodium sulfate
Synonyms:
  • SCS
  • SODIUM CHOLESTERYL SULFATE
  • CHOLESTEROL 3 SULFATE SODIUM
  • 5-cholesten-3β-ol sulfate sodium salt
  • CHOLESTEROL SULFATE SODIUM (SCS)
  • SODIUM CHOLESTEROL SULFATE
  • (3)-Cholest-5-en-3-ol 3-(Hydrogen Sulfate) Sodium Salt
  • CHOLESTERYL SODIUM SULFATE
CAS:
2864-50-8
MF:
C27H47NaO4S
MW:
490.72
Product Categories:
  • Pharmaceuticals
  • Steroids
  • Steroids & Hormones - 13C & 2H
  • Intermediates & Fine Chemicals
Mol File:
2864-50-8.mol
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Cholesteryl sodium sulfate Chemical Properties

Melting point:
178-180°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Methanol (Slightly, Heated)
form 
White to off-white powder.
color 
White to Off-White
biological source
synthetic
BRN 
3899884
InChIKey
ZKMOLHRAYRDKHW-SMRZMENRNA-N
SMILES
C[C@]12CC[C@H](OS(O)(=O)=O)CC1=CC[C@@]1([H])[C@]3([H])CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]3(C)CC[C@]21[H].[NaH] |&1:1,4,14,16,20,22,30,34,r|
CAS DataBase Reference
2864-50-8(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
F 
3-10

MSDS

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Cholesteryl sodium sulfate Usage And Synthesis

Description

Cholesterol sulfate is an endogenous component of cell membranes where it serves as a substrate for steroid synthesis, influences lipid metabolism, stabilizes cell membranes, regulates the activity of functional proteins, and plays a role in keratinocyte differentiation and development of the epidermal barrier. This synthetic formulation can be used to form nonconventional liposomes in order to study cellular membrane properties.

Chemical Properties

White to Off-White Solid

Uses

Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones.

in vivo

Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 6 days) antagonizes acute ulcerative colitis induced by DSS (HY-116282C) in male C57BL/6J mice, prevents weight loss, colon shortening and tissue damage, and reverses the exacerbated symptoms in Sult2b1△IEC mice[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 33 days) improves survival and reduces inflammation in male C57BL/6J mice with chronic colitis induced by DSS[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 42 days) alleviates spontaneous colitis caused by IL-10 deficiency in female IL-10-/- mice and reduces body weight loss and tissue damage[2].
Cholesteryl sulfate sodium (SCS) can synergize with Mitoxantrone hydrochloride (HY-13502A) to exert antitumor activity through a nano-delivery system[3].

References

[1] CHARLES A STROTT  Yuko H. Cholesterol sulfate in human physiology: what’s it all about?[J]. Journal of Lipid Research, 2003, 44 7: 1268-1278. DOI: 10.1194/jlr.r300005-jlr200

Cholesteryl sodium sulfateSupplier

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Cholesteryl sodium sulfate(2864-50-8)Related Product Information