Domagrozumab
Domagrozumab Basic information
- Product Name:
- Domagrozumab
- Synonyms:
-
- Domagrozumab
- Research Grade Domagrozumab(DHA30603)
- Research Grade Domagrozumab
- Domagrozumab (anti-GDF8)
- CAS:
- 1629605-31-7
- MW:
- 0
- Mol File:
- Mol File
Domagrozumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Domagrozumab Usage And Synthesis
Uses
Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].
in vivo
Domagrozumab (PF-06252616; 10 and 30 mg/kg; i.v.) increases myostatin levels in a dose-dependent manner and induces skeletal muscle hypertrophy in cynomolgus monkeys[1].
References
[1] St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7(1):25. DOI:10.1186/s13395-017-0141-y
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